Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines

Bioorg Med Chem Lett. 2000 Mar 6;10(5):415-8. doi: 10.1016/s0960-894x(00)00011-1.

Abstract

Synthesis and biological evaluation of 6-thiophene 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives resulted in a number of potent nonsteroidal antiprogestins.

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism
  • Cell Line
  • Cross Reactions
  • Fibroblasts
  • Haplorhini
  • Humans
  • Mice
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology
  • Receptors, Progesterone / antagonists & inhibitors*
  • Receptors, Progesterone / genetics
  • Structure-Activity Relationship
  • Thiophenes / chemical synthesis*
  • Thiophenes / pharmacology
  • Transfection
  • Tumor Cells, Cultured

Substances

  • Quinolines
  • Receptors, Progesterone
  • Thiophenes